New research indicates that individuals who come off popular slimming jabs like semaglutide or tirzepatide can put back on lost weight at a significantly accelerated pace than those who stop conventional diet and exercise plans.
Findings released in a major health publication demonstrates that while overweight people often shed substantial amounts of their total mass while on the medication, the weight comes back at an average rate of 0.8 kg per month once they quit.
"People using these drugs must be informed of the potential of rapid rebound weight gain when the treatment ends," stated researcher Dr. Susan Jebb.
This pace of regain means a return to original mass within about 18 months.
Comparing Approaches
The analysis, which reviewed 37 of trials involving over 9,000 of patients, contrasted the results of the injectable medications with conventional dieting.
Researchers note that individuals who shed pounds through lifestyle changes alone generally experience a less rapid weight regain—perhaps 100 grams monthly—once they finish.
The Reason for the Rapid Rebound
Doctors propose the way of the injections is key to understanding the accelerated regain.
These medications mimic a body's own chemical called GLP-1, which moderates appetite.
"Artificially providing the hormone levels several times higher than the body's typical production might result in the system to generate a reduced amount of its own natural hormone, and may also diminish responsiveness to its effects," said Dr. Adam Collins, a dietetics specialist.
"Discontinuation of this GLP-1 'fix' leads to hunger is uncontrolled, making excessive eating far more likely."
An Ongoing Issue?
Health authorities advise the jabs for people with obesity-related health risks, accompanied by recommended diet and exercise modifications.
Many experts argue that, due to the likelihood of weight regain, the therapy is often life-long.
This opinion is reinforced by pharmaceutical companies, who say that the results "highlight the chronic nature of obesity," comparing it to managing diseases like high blood pressure.
Patient Testimonies
Users who have discontinued the medication explain a sudden return of hunger.
"I experienced a trigger flipping and you're instantly starving," described a patient.
This difficulty is worsened if users have not established permanent dietary or behavioural modifications during therapy.
Significant Use
Figures suggest that millions of people in the UK have used these injections in the past year, with interest being substantial.
- Use is more common among women compared to men.
- The middle-aged age group shows the greatest level of interest.
- A large proportion access the drugs through private prescriptions rather than public health services.
In conclusion, clinicians caution that while the jabs are effective agents for weight loss, they are not a standalone cure and maintained weight loss likely depends on combined behavioural changes.
